Legalized marijuana. It's coming to canada and I want to try it.
Study shows white matter damage may be caused by 'skunk-like' cannabisPosted on 27/11/2015
The corpus callosum
Smoking high potency ‘skunk-like’ cannabis can damage a crucial part of the brain responsible for communication between the two brain hemispheres, according to a new study by scientists from King’s College London and Sapienza University of Rome.
Researchers have known for some time that long-term cannabis use increases the risk of psychosis, and recent evidence suggests that alterations in brain function and structure may be responsible for this greater vulnerability. However, this new research, published today in Psychological Medicine, is the first to examine the effect of cannabis potency on brain structure.
Exploring the impact of cannabis potency is particularly important since today’s high potency ‘skunk-like’products have been shown to contain higher proportions of Δ9-tetrahydrocannabinol (THC) than they did around a decade ago. In experimental studies THC has been shown to induce psychotic symptoms and ‘skunk-like’ products high in THC are now thought to be the most commonly used form of cannabis in the UK.
Dr Paola Dazzan, Reader in Neurobiology of Psychosis from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London, and senior researcher on the study, said: ‘We found that frequent use of high potency cannabis significantly affects the structure of white matter fibres in the brain, whether you have psychosis or not.
‘This reflects a sliding scale where the more cannabis you smoke and the higher the potency, the worse the damage will be.’
Diffusion Tensor Imaging (DTI), a Magnetic Resonance Imaging (MRI) technique, was used to examine white matter in the brains of 56 patients who had reported a first episode of psychosis at the South London and Maudsley NHS Foundation Trust (SLaM), as well as 43 healthy participants from the local community.
The researchers specifically examined the corpus callosum, the largest white matter structure in the brain, which is responsible for communication between the left and right hemispheres. White matter consists of large bundles of nerve cell projections (called axons), which connect different regions of the brain, enabling communication between them.
The corpus callosum is particularly rich in cannabinoid receptors, on which the THC content of cannabis acts.
The study found that frequent use of high potency cannabis was linked to significantly higher mean-diffusivity (MD), a marker of damage in white matter structure.
Dr Tiago Reis Marques, a senior research fellow from the IoPPN at King’s College London, said: ‘This white matter damage was significantly greater among heavy users of high potency cannabis than in occasional or low potency users, and was also independent of the presence of a psychotic disorder.’
Dr Dazzan added: ‘There is an urgent need to educate health professionals, the public and policymakers about the risks involved with cannabis use.
‘As we have suggested previously, when assessing cannabis use it is extremely important to gather information on how often and what type of cannabis is being used. These details can help quantify the risk of mental health problems and increase awareness on the type of damage these substances can do to the brain.’
This research was funded primarily by the NIHR Biomedical Research Centre at the South London and Maudsley (SLaM) NHS Foundation Trust and King's College London.The study was led by Dr Tiago Reis Marques and Dr Paola Dazzan of the IoPPN at King’s, and Dr Silvia Rigucci of Sapienza University of Rome.
Being a smoker for years, I would have to say Muddy Waters says it all....
First time I tried it nothing happened. Second time my friends brother came over to her house and smoked with us in a dark room listening to Black Sabbath , name of the song was Black Sabbath too. NOT a good idea being that I still believed in demons then. It was so horrible....... I remember the song saying " satan's sitting there, he's smiling. ( I think I got punked) Ha ha it was NOT funny....Did not smoke for awhile after that but being that most of my friends smoked I tried it again and ended up really liking it.
For me it gives me energy. I want to put some good music on, clean my house and make it pretty.
If I am hungry and smoke one, I'm not hungry anymore.. My sister is the same way.
Some others will just sit around and eat . Everyone is not the same. One of my friends hates pot because when she smokes she feels FAT.
I would take a joint over alcohol any day. If you end up liking it you may want to get a second job, it's not cheap ! LOL
What's with all the bullshit? They don't even define "skunk-like" cannabis. Fear mongering bullshit.
It's very easy to find shit like this, virtually every bit of research ever funded into cannanbis is looking for negatives.
Studies into the therapeutic value of cannabis are much harder to find.
I think skunk might be the smell such like cannabis has that has the supper high THC content they may also be high in that particular terpinoid that smells like a skunk.
Thanks for the info on skunk I've only had it a couple of times and tend to stay away from stuff that inhibits communication between both hemispheres of the brain. How about the effects of listening and playing music while under the influence under influence of low concentrations of THC and high concentrations CBD I wounder they would tells us about this type of brain cross talk?
ealth benefits of music
Listening to music feels good, but can that translate into physiological benefit? Levitin and colleagues published a meta-analysis of 400 studies in the journal Trends in Cognitive Sciences, suggesting the answer is yes.In one study reviewed, researchers studied patients who were about to undergo surgery. Participants were randomly assigned to either listen to music or take anti-anxiety drugs. Scientists tracked patient's ratings of their own anxiety, as well as the levels of the stress hormone cortisol.
The results: The patients who listened to music had less anxiety and lower cortisol than people who took drugs. Levitin cautioned that this is only one study, and more research needs to be done to confirm the results, but it points toward a powerful medicinal use for music.
I smoked pot in the 70s three different times. It was at party gatherings each time. I never enjoyed the effect. Just made me feel dizzy and carsick.
But I'm all for adults to do as they like about that kind of thing. Dope should be legal just as liquor and cigarettes and maybe it would cut down on the crime. Just like the end of Prohibition did.
Weed has not got more potent over the decades. That is bullshit. Landrace strains exist now that have very high THC. The genetic strength of weed hasn't been going through rapid evolution since the 70's.
This shit gets thrown around heaps. Simply repeating something over and over doesn't make it true
2=2 every objection raised here is just met with your response "bullshit" I suggest you may need to do some more research or pay attention to folks you may know who are long term users, to call every objection or well rounded response as "bullshit" proves to be very unhelpful and pointless
5 I don't know but my pot smoking early days were 67-72and then a 29 year abstinance then resuming. I remember tripping out on ten fat dubbies full of acopoco gold smoked in rapid succession and having the earth swallow me up after my friend seen a flying saucer land on the lake, woke next morning a little groggy but ok. But my reintroduction 29 years latter I can testify was way more potent and caused more paranoia.
A potent and very stable growing indica/Sativa hybrid that was renowned for it's strong odour, ease of growth with a high yield and potency.
Thats all skunk really is kids, dank weed with a particular terpene profile that's sought out by cannabis connoisseur's.
What objection? I have only objected to the common misconsceptions that are being repeated here. Cannabis is not physically addictive, it has not gotten stronger in the last 40 years.
I have already posted that it can be dangerous and harmfull.