PSac - Don't sulk!
Cantleave started this thread to put together a collection of pieces of evidence for the common ancestry of all life.
In future when people lazily throw around lines like "there is no evidence for evolution" or they think that humans are an exception we can link here and the hard work is already done. I'm sure it will continue to grow as a repository of evidence.
Hopefully it is clearing up some misconceptions and motivating some to read further. Of course your questions are welcome but copy-pasting articles that don't address the point doesn't help the discussion.
That some mutations are being found to be NOT as random as others is a fact and all I wanted to point out.
On the contrary. It is the location of mutations that are not entirely random. This in no way changes the fact that they are " random and purposeless ".
Remember our genome is made up of around 3 billions bases. It contains only 4 letters A,C,G & T and these are read off in groups of 3 called codons.
Each codon codes for one of 20 amino acids. Some amino acids are coded for by more than one codon.
When a mutation occurs and a letter is deleted for example it can have a huge effect on the next section of the gene.
For example consider the SWS opsin gene that codes for the cells that detect blue light.
We know that dolphins descended from a common ancestor of cows.
In cows the code reads...
TTT CTT CTG TTC AAG AAC ATC TCC TTG
Each of these codons codes for an amino acid which combine to make the protein.
In dolphins four of these letters have been deleted by random mutations so it reads...
TTT *TT CTG TTC AAG AAC AT* *** TTG
These are then read of as...
TTT TTC TGT TCA AGA ACA TTT G..
Which is a completely different set of amino acids which leaves the gene nonfunctional and the dolphin with no colour vision.
Later I will post about other more fortuitous mutations that resulted in improved mutations in humans and our primate cousins.
I hope this illustrates what we mean when we say that mutations are 100% random. The fact that there are some areas of the genome that are more likely to suffer mutations than other sections does not change this fact.
Feel free to ask lots of questions Psac.