"Biblically the answer is very simple: mankind exercise their freedom of choice and in so doing chose to be slaves to sin or the demons if you like. God respects that choice however foolish it may be. Alienation from the life of God, of the Spirit, is the central problem is it not?"
Wow, this is like right out of a Watchtower. It’s just like the Watchtower, in that it attempts to create the notion that only bad things happen to "bad" people (such as people who don't fit into expected doctrinal beliefs), ergo God doesn’t interfere there. Everything is either black or white, on or off, or, right or wrong, with this kind of thinking. As if, only bad or sinful people die in natural disasters and calamities. They brought this on themselves because they decidied to alienate themselves from God? Its easy to take the view that God doesn't interfere in people's lives who seem to be living sinful lives and then bad things happen to them (AIDS for instance?). But what about when bad things happen to those that you believe have not alienated themselves from God? Did God not intervene/interfere in their life and help them because maybe there was some great hidden sin in their life? Nah. It just happens. I don’t pretend to understand it.
Look, bad things happen to bad people and bad things happen to good people, and neither is because God decided not to interfere, IMO. No one understands the reasons behind these things. If you believe in God, and you perceive that God is not interfering (or intervening) in peoples lives, don’t make the assumption that this is because these people have created their situation and alienated themselves from God. Job was one who lived a righteous life and look what happened to him. I don’t believe things happen at random, but I also don’t understand why God doesn’t (seemingly)interfere/intervene more in people’s lives who I believe to be godly folks when things go way bad for them. We may never have the answers for this problem. But please don't try and make a simple formula for why it seems that God isn't busy at His work in people's lives. He is, but we aren't always allow to see the reasons for the things He does.