British Journal of Anaesthesia
Notice of formal retraction of articles by Dr Joachim Boldt
The Editorial Board of the British Journal of Anaesthesia has been informed by the Landesärztekammer Rheinland-Pfalz (‘LÄK-RLP’), the State Medical Association of Rheinland-Pfalz, Germany that serves as the Institutional Review Board (IRB) for clinical research at Klinikum Ludwigshafen, where Dr Joachim Boldt's recent research was conducted, that they have completed a systematic evaluation of the status of IRB approval for research conducted by Dr Boldt dating back to 1999. They were unable to verify IRB approval for 11 articles published in the British Journal of Anaesthesia between 1999 and 2009.
The editors of the BJA have therefore, in accordance with the journal's regulations, retracted the following articles authored by Dr Boldt and previously published in the journal.
Mayer J, Boldt J, Beschmann R, Stephan A, Suttner S. Uncalibrated arterial pressure waveform analysis for less-invasive cardiac output determination in obese patients undergoing cardiac surgery. Br J Anaesth 2009; 103: 185–90 (doi: 10.1093/bja/aep133)
Suttner S, Boldt J, Mengistu A, Lang K, Mayer J. Influence of continuous perioperative beta-blockade in combination with phosphodiesterase inhibition on haemodynamics and myocardial ischaemia in high-risk vascular surgery patients. Br J Anaesth 2009; 102: 597–607 (doi: 10.1093/bja/aep062)
Boldt J, Suttner S, Brosch C, Lehmann A, Mengistu A. Influence on coagulation of a potato-derived hydroxethylstarch (HES 130/0.42) and a maize-derived hydroxethylstarch (HES 130/0.4) in patients undergoing cardiac surgery. Br J Anaesth 2009; 102: 191–7 (doi: 10.1093/bja/aen353)
Boldt J, Brosch Ch, Röhm K, Papsdorf M, Mengistu A. Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patients. Br J Anaesth 2008; 100: 457–64 (doi: 10.1093/bja/aen016)
Mayer J, Boldt J, Schöllhorn T, Röhm KD, Mengistu AM, Suttner S. Semi-invasive monitoring of cardiac output by a new device using arterial pressure waveform analysis: a comparison with intermittent pulmonary artery thermodilution in patients undergoing cardiac surgery. Br J Anaesth 2007; 98: 176–82 (doi: 10.1093/bja/ael341)
Piper SN, Röhm KD, Boldt J, Faust KL, Maleck WH, Kranke P, Suttner SW. Inspired oxygen fraction of 0.8 compared with 0.4 does not further reduce postoperative nausea and vomiting in dolasetron-treated patients undergoing laparoscopic cholecystectomy. Br J Anaesth 2006; 97: 647–53 (doi: 10.1093/bja/ael242)
Boldt J, Haisch G, Suttner S, Kumle B, Schellhaass A. Effects of a new modified, balanced hydroxyethyl starch preparation (Hextend) on measures of coagulation. Br J Anaesth 2002; 89: 722–8 (doi:10.1093/bja/aef242)
Boldt J, Hüttner I, Suttner S, Kumle B, Piper SN, Berchthold G. Changes of haemostasis in patients undergoing major abdominal surgery–is there a difference between elderly and younger patients? Br J Anaesth 2001; 87: 435–40 (doi: 10.1093/bja/87.3.435)
Suttner SW, Piper SN, Lang K, Hüttner I, Kumle B, Boldt J. Cerebral effects and blood sparing efficiency of sodium nitroprusside-induced hypotension alone and in combination with acute normovolaemic haemodilution. Br J Anaesth 2001; 87: 699–705 (doi: 10.1093/bja/87.5.699)
Hüttner I, Boldt J, Haisch G, Suttner S, Kumle B, Schulz H. Influence of different colloids on molecular markers of haemostasis and platelet function in patients undergoing major abdominal surgery. Br J Anaesth 2000; 85: 417–23
Boldt J, Weber A, Mailer K, Papsdorf M, Schuster P. Acute normovolaemic haemodilution vs controlled hypotension for reducing the use of allogeneic blood in patients undergoing radical prostatectomy. Br J Anaesth 1999; 82: 170–4
LÄK-RLP was unable to verify IRB approval for 88 articles by Dr Boldt published in 18 different journals, including the British Journal of Anaesthesia between 1999 and 2009. A full list of all 88 articles involved is available on our website.
Lack of IRB approval means that the research was unethical, and that IRB approval for the research was misrepresented in the published article. It does not mean that the research results per se are fraudulent. Klinikum Ludwigshafen has commissioned an investigating committee to systematically assess the veracity of the findings presented in Dr Boldt's articles against patient and laboratory records. We will communicate to our readers any finding of data fabrication, falsification, or misrepresentation identified by the investigating committee at Klinikum Ludwigshafen.
The Editorial Board and publishers of the British Journal of Anaesthesia extend our appreciation to LÄK-RLP for their review of the status of IRB approval for Dr Boldt's research and to the investigating committee at Klinikum Ludwigshafen for their ongoing review of his research findings.
Professor Charles Reilly
Editor-in-Chief, on behalf of the Directors and Editorial Board of the British Journal of Anaesthesia
Another retraction from BJA
The article below is being retracted following an investigation by the Justus-Liebig Universität Giessen of the work done by Joachim Boldt during his time there, as there is significant doubt regarding the veracity of this publication.
Boldt J, Mueller M, Menges T, Papsdorf M, Hempelmann G. Influence of different volume therapy regimens on regulators of the circulation in the critically ill. Br J Anaesth 1996; 77: 480-7 (doi:10.1093/bja/77.4.480)