I would recommend having a calm, rational conversation with your wife.I would start by reading her Luke 14:28-32.
28 For example, who of you wanting to build a tower does not first sit down and calculate the expense to see if he has enough to complete it? 29 Otherwise, he might lay its foundation but not be able to finish it, and all the onlookers would start to ridicule him, 30 saying: ‘This man started to build but was not able to finish.’ 31 Or what king marching out against another king in war does not first sit down and take counsel whether he is able with 10,000 troops to stand up to the one who comes against him with 20,000? 32 If, in fact, he cannot do so, then while that one is yet far away, he sends out a body of ambassadors and sues for peace.
I would sit down at the dining table with pencil and paper. Chart a typical week Sunday through Saturday. Figure out when everything required to run the household will be completed and when you will make time for each other to maintain your relationship.
As previous posters have mentioned that there are only so many hours in a day and so many days in a week. Be sure you make it clear that you love your wife and you are not willing to sacrifice your marriage so she can spend even more time in the ministry. Compliment your wife's zeal, but also remind her that Pioneering is not scripturally required to gain everlasting life.