When I look at my own life in trying to help others, it's always "in spite of" me because inevitably I would fail in "my" efforts, but the person gets helped anyway! I believe God does his best work "in spite of" humanity, but still uses humanity to do it...even government sometimes!
You should be careful here. The many millions of dead, slaughtered in the killing fields of totalitarian governments, surely wasn’t “God using humanity” for “his best work.”