I have Logitech desksets at home and at work, a better one at home, but the keyboard layouts are identical new-style ones with big delete keys. Main difference is the mouse in the home set is rechragble with etra buttons hereas the work one is ordinary battery powered.
The number/cap/F lock lights are in the receiver if it is a wireless jobby.
Layout is not too bad but I really don't use all the funky extra buttons and controls much I'm so used to a standard keyboard. I'm a really fast four-finger typist, a bit up from hunt and peck but not a touch typist, so small layout chnages don't other me as much.
Main issue is my work deskset is demonised; random key entry and mouse movements plauge me (must besome other bastard with the same keyboard but I can't find it), and the beginings of RSI in my right wrist; fels like the tendons are rubing together in a bad way.
But my pain perception is weird; I normally miss minor cuts and bruises until someone else points them out. It might actually be really pinful but not to me.
Keep meaning to get someone to look at it.