“We are only now starting to realize what happens to blood when it is drawn out of a human body and sent to the blood bank for storage. Blood undergoes changes profoundly, even in the first 24 hours. The major effect is loss of nitric oxide, which is really fundamental to the process of oxygen exchange.” --Justpassing
Dear justpassing, your quote is alarmist and misleading. Vasoconstriction is a normal physiological response to severe hemorrhage, caused not by blood transfusion but by the human body itself as an attempt to raise blood pressure to vital organs.
A vasodilator (nitric-oxide synthase or nitric acid?) can be applied separately, depending on the patient's body mass.
The issue is like that of blaming your car becuse it has no kitchen to cook the food you just loaded at the market. The car is only a vehicle to transport it from the market to your house. Similarly, the blood transfusion will only replace lost cells; if the patient needs more volume, you add isotonic solution, if he needs vasodilators, you add them; if he needs additional oxygen, you supply it; need clotting factors, you apply them; need platelets, you apply them, etc. There is not one medication cocktail that will manage all your physiology upon transfusion....although biotech companie$ would want you to believe you need it.
The documents i have come across regarding nitric oxide in banked blood for vasodilation or platelet activation are all sponsored by biotech companies that want to sell their drug cocktail. Of course, their view is commercially slanted for finantial gain from a "ready to sell" product" that most patients will not benefit from.
Unfortunately, the WT is ready to blow such alarmist commercial claims out of proportion for their own benefit.