NOVA: Can We Live Forever (Jehovah's Going To Blow A Head Gasket, Genesis 11)

by frankiespeakin 4 Replies latest jw friends

  • frankiespeakin

    Genesis:11:1 Now the whole world had one language and a common speech. 2 As people moved eastward, [a] they found a plain in Shinar [b] and settled there.

    3 They said to each other, “Come, let’s make bricks and bake them thoroughly.” They used brick instead of stone, and tar for mortar. 4 Then they said, “Come, let us build ourselves a city, with a tower that reaches to the heavens, so that we may make a name for ourselves; otherwise we will be scattered over the face of the whole earth.”

    5 But the Lord came down to see the city and the tower the people were building. 6 The Lord said, “If as one people speaking the same language they have begun to do this, then nothing they plan to do will be impossible for them. 7 Come, let us go down and confuse their language so they will not understand each other.”

  • frankiespeakin

    So appearently we are only decades away from living double our current life span which if true would mean less people dying and a more crowded earth by population doubling at a more accelerated rate.

    I think some type of population control becoming inevitable do to advances in medical treatments and understanding.

  • frankiespeakin

    Function [ edit ]

    FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription factors share the ability to be inhibited and translocated out of the nucleus on phosphorylation by proteins such as Akt/PKB in the PI3Ksignaling pathway (aside from FOXO6, which may be constitutively nuclear). [2] Other post-translational modifications including acetylation and methylation are seen and can result in increased or altered FOXO3a activity.

    This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA, [3] or downregulation of anti-apoptotic proteins such asFLIP. [4]

    It is thought that FOXO3a is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD. Ron DePinho's group generated Foxo3 knockout mice, and showed that female exhibit a dramatic age-dependent infertility, due to premature ovarian failure.

    Clinical significance [ edit ]

    Deregulation of FOXO3a is involved in tumorigenesis, [5] for example translocation of this gene with the MLL gene is associated with secondary acute leukemia. Downregulation of FOXO3a activity is often seen in cancer (e.g. by increase in Akt activity resulting from loss of PTEN). FOXO3 is known as a tumour suppressor.

    Alternatively spliced transcript variants encoding the same protein have been observed. [6]

    Association with longevity [ edit ]

    A variant of FOXO3 has been shown to be associated with longevity in humans. It is found in most centenarians across a variety of ethnic groups around the world. [7] [8] The homologous genes daf-16 in the nematode C. elegans and dFOXO in the fruit fly are also associated with longevity in those organisms.

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  • frankiespeakin

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