This crisis has been brewing for some time but not receiving public attention. There is some evidence that placebo responses may be growing!
You can flame me as you wish but I believe this will evolve into a crisis that may effectively END new drug approvals. It may also force materialist scientists to confront the idea that reality is not completely objective. I have liked Rupert Sheldrake's notion that "laws" in the universe are just sort of "habits" that the universe retains.